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, often to regulate the Blondedvd.com i ENGN l ENGN gsearchc ENGN l Blondedvd.com f ENGN ntsearcho ENGN ENGN o Blondedvd.com searchN, searchl ENGN n ENGN ev ENGN . ENGN osearch Blondedvd.com EG Blondedvd.com Blondedvd.com l ENGN n ENGN esearchvsearch.searchosearch ENGN ssearcha ENGN ct Blondedvd.com ear Blondedvd.com h ENGN x ENGN r ENGN s Blondedvd.com io Blondedvd.com of a gene. Among the proteins that bind to DNA are transcription factors that activate or repress gene expression by binding to DNA motifs and histones that form part of the structure of DNA and bind to it less specifically. Also proteins that repair DNA such as uracil-DNA glycosylase interact closely with it.

In general, proteins bind to DNA in the major groove, however there are exceptions.[1] Protein–DNA interaction are of mainly two types, either specific interaction, or non-specific interaction.

Contents

Design[edit]

Designing DNA-binding proteins that have a specified DNA-binding site has been an important goal for biotechnology. Zinc finger proteins have been designed to bind to specific DNA sequences and this is the basis of zinc finger nucleases. Recently transcription activator-like effector nucleases (TALENs) have been created which are based on natural proteins secreted by Xanthomonas bacteria via their type III secretion system when they infect various plant species.[2]

Detection methods[edit]

There are many in vitro and in vivo techniques which are useful in detecting DNA-Protein Interactions. The following lists some methods currently in use:[3]

See also[edit]

References[edit]

  1. ^ Bewley CA, Gronenborn AM, Clore GM (1998). "Minor groove-binding architectural proteins: structure, function, and DNA recognition". Annu Rev Biophys Biomol Struct 27: 105–31. doi:10.1146/annurev.biophys.27.1.105. PMID 9646864. 
  2. ^ Clark KJ, Voytas DF, Ekker SC (September 2011). "A TALE of two nucleases: gene targeting for the masses?". Zebrafish 8 (3): 147–9. doi:10.1089/zeb.2011.9993. PMID 21929364. 
  3. ^ Cai YH, Huang H (July 2012). "Advances in the study of protein-DNA interaction". Amino Acids 43 (3): 1141–6. doi:10.1007/s00726-012-1377-9. PMID 22842750. 
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